实验性移植艾氏癌和B16黑色素瘤复发与转移的特异性
Specificity of relapses and metastases of experimental transplanted Ehrlich carcinoma and B16 melanoma.
作者信息
Sitdikova S M, Amandzholov B S, Kiselevskii M V, Donenko F V
机构信息
N. N. Blokhin National Oncological Research Center, Russian Academy of medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2007 Jan;143(1):80-2. doi: 10.1007/s10517-007-0022-1.
PMID:18019019
Abstract
Experiments on female (CBAxC57Bl/6)F1 mice with simultaneously transplanted Ehrlich carcinoma and B16 melanoma showed that removal of one of the primary nodes led to metastasizing of the removed tumor alone. It seems that this specificity of the inhibitory effect of the primary tumor can be explained by peculiarities of glycosylation and subsequent complex formation of serum proteins with the tumor.
摘要
对同时移植了艾氏癌和B16黑色素瘤的雌性（CBAxC57Bl/6）F1小鼠进行的实验表明，切除其中一个原发瘤结节会导致仅被切除的肿瘤发生转移。原发肿瘤抑制作用的这种特异性似乎可以通过糖基化特性以及血清蛋白随后与肿瘤形成复合物来解释。
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