在轻度认知障碍和阿尔茨海默病中，血浆抗氧化剂同样会减少。

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.

作者信息

Rinaldi P, Polidori M C, Metastasio A, Mariani E, Mattioli P, Cherubini A, Catani M, Cecchetti R, Senin U, Mecocci P

机构信息

Department of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce-Pad. E, Via Brunamonti 51, 06126 Perugia, Italy.

出版信息

Neurobiol Aging. 2003 Nov;24(7):915-9. doi: 10.1016/s0197-4580(03)00031-9.

DOI:10.1016/s0197-4580(03)00031-9

PMID:12928050

Abstract

In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids including lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha- and beta-carotene) antioxidant micronutrients as well as activities of plasma and red blood cell (RBC) superoxide dismutase (SOD) and of plasma glutathione peroxidase (GPx) were measured in 25 patients with MCI, 63 AD patients and 53 controls. Peripheral levels and activities of antioxidants were similarly lower in MCI and AD patients as compared to controls. As MCI may represent a prodromal stage of AD, and oxidative damage appears to occur as one of the earliest pathophysiological events in AD, an increased intake of antioxidants in patients with MCI could be helpful in lowering the risk of conversion to dementia.

摘要

为了评估轻度认知障碍（MCI）和阿尔茨海默病（AD）老年患者体内多种非酶和酶类抗氧化剂的外周水平及活性，我们检测了25例MCI患者、63例AD患者和53例对照者血浆中水溶性抗氧化微量营养素（维生素C和尿酸）及脂溶性抗氧化微量营养素（维生素A、维生素E和类胡萝卜素，包括叶黄素、玉米黄质、β - 隐黄质、番茄红素、α - 和β - 胡萝卜素）的水平，以及血浆和红细胞（RBC）中超氧化物歧化酶（SOD）的活性和血浆谷胱甘肽过氧化物酶（GPx）的活性。与对照组相比，MCI患者和AD患者体内抗氧化剂的外周水平及活性同样较低。由于MCI可能是AD的前驱阶段，且氧化损伤似乎是AD最早出现的病理生理事件之一，因此增加MCI患者抗氧化剂的摄入量可能有助于降低其转化为痴呆症的风险。