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本文引用的文献

1
Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1.野生型铜绿假单胞菌PAO1中消毒剂诱导多药外排泵mexCD-oprJ操纵子的表达
J Antimicrob Chemother. 2003 Apr;51(4):991-4. doi: 10.1093/jac/dkg173. Epub 2003 Mar 13.
2
Roles of MexXY- and MexAB-multidrug efflux pumps in intrinsic multidrug resistance of Pseudomonas aeruginosa PAO1.MexXY和MexAB多药外排泵在铜绿假单胞菌PAO1固有多药耐药性中的作用。
J Gen Appl Microbiol. 2001 Feb;47(1):27-32. doi: 10.2323/jgam.47.27.
3
The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.铜绿假单胞菌的MexJK外排泵进行抗生素外排需要OprM，但三氯生外排则不需要。
J Bacteriol. 2002 Sep;184(18):5036-44. doi: 10.1128/JB.184.18.5036-5044.2002.
4
Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.对铜绿假单胞菌中一种新的赋予钒抗性的外排泵MexGHI-OpmD的特性分析。
Microbiology (Reading). 2002 Aug;148(Pt 8):2371-2381. doi: 10.1099/00221287-148-8-2371.
5
Construction of a series of mutants lacking all of the four major mex operons for multidrug efflux pumps or possessing each one of the operons from Pseudomonas aeruginosa PAO1: MexCD-OprJ is an inducible pump.构建一系列缺乏用于多药外排泵的所有四个主要mex操纵子的突变体，或拥有来自铜绿假单胞菌PAO1的每个操纵子：MexCD-OprJ是一种诱导型泵。
FEMS Microbiol Lett. 2001 Aug 7;202(1):139-43. doi: 10.1111/j.1574-6968.2001.tb10794.x.
6
Molecular properties of bacterial multidrug transporters.细菌多药转运蛋白的分子特性
Microbiol Mol Biol Rev. 2000 Dec;64(4):672-93. doi: 10.1128/MMBR.64.4.672-693.2000.
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.铜绿假单胞菌PAO1（一种机会致病菌）的全基因组序列
Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.
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Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.MexX-MexY-oprM 外排系统对铜绿假单胞菌固有耐药性的作用
Antimicrob Agents Chemother. 2000 Sep;44(9):2242-6. doi: 10.1128/AAC.44.9.2242-2246.2000.
9
The multidrug efflux protein NorM is a prototype of a new family of transporters.多药外排蛋白NorM是一个新的转运蛋白家族的原型。
Mol Microbiol. 1999 Jan;31(1):394-5. doi: 10.1046/j.1365-2958.1999.01162.x.
10
Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.铜绿假单胞菌新型多药外排泵MexXY在大肠杆菌中的表达
Antimicrob Agents Chemother. 1999 Feb;43(2):415-7. doi: 10.1128/AAC.43.2.415.

从铜绿假单胞菌突变体中对多药外排泵mexHI-opmD进行功能克隆及特性分析。

Functional cloning and characterization of a multidrug efflux pump, mexHI-opmD, from a Pseudomonas aeruginosa mutant.

作者信息

Sekiya Hiroshi, Mima Takehiko, Morita Yuji, Kuroda Teruo, Mizushima Tohru, Tsuchiya Tomofusa

机构信息

Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan.

出版信息

Antimicrob Agents Chemother. 2003 Sep;47(9):2990-2. doi: 10.1128/AAC.47.9.2990-2992.2003.

DOI:10.1128/AAC.47.9.2990-2992.2003
PMID:12937010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC182609/
Abstract

We isolated mutant YM644, which showed elevated resistance to norfloxacin, ethidium bromide, acriflavine, and rhodamine 6G, from Pseudomonas aeruginosa YM64, a strain that lacks four major multidrug efflux pumps. The genes responsible for the resistance were mexHI-opmD. Elevated ethidium extrusion was observed with cells of YM644 and YM64 harboring a plasmid carrying the genes. Disruption of the genes in the chromosomal DNA of YM644 made the cells sensitive to the drugs.

摘要

我们从缺乏四种主要多药外排泵的铜绿假单胞菌YM64中分离出了突变体YM644，该突变体对诺氟沙星、溴化乙锭、吖啶黄素和罗丹明6G表现出更高的抗性。负责这种抗性的基因是mexHI-opmD。携带这些基因的质粒的YM644和YM64细胞观察到溴化乙锭外排增加。YM644染色体DNA中的基因破坏使细胞对这些药物敏感。