厚脉胡椒中的抗真菌黄烷酮和异戊烯基对苯二酚。

Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth.

作者信息

Danelutte Ana Paula, Lago João Henrique G, Young Maria Claudia M, Kato Massuo J

机构信息

Instituto de Química, Universidade de São Paulo, C.P. 26077, CEP 05599-970, São Paulo, SP, Brazil.

出版信息

Phytochemistry. 2003 Sep;64(2):555-9. doi: 10.1016/s0031-9422(03)00299-1.

DOI:10.1016/s0031-9422(03)00299-1

PMID:12943774

Abstract

Bioactivity-guided fractionation of the EtOAc extract from leaves of Piper crassinervium yielded three prenylated hydroquinones together with two known flavanones naringenin and sakuranetin. Their structures were determined by means of spectroscopic analysis (NMR, IR, UV and MS) including two-dimensional NMR spectroscopy experiments (1H-1H COSY, HMQC, HMBC and NOESY). The antifungal activity was determined by direct bioautography against Cladosporium cladosporioides and C. sphaerospermum.

摘要

对粗脉胡椒叶乙酸乙酯提取物进行生物活性导向分离，得到了三种异戊烯基对苯二酚以及两种已知的黄烷酮柚皮素和樱花素。通过光谱分析（核磁共振、红外、紫外和质谱），包括二维核磁共振光谱实验（1H-1H COSY、HMQC、HMBC和NOESY）确定了它们的结构。通过直接生物自显影法测定了对枝孢菌和球孢枝孢菌的抗真菌活性。