来自多毛胡椒叶的抗真菌酰胺。

Antifungal amide from leaves of Piper hispidum.

作者信息

Alécio A C, da Silva Bolzani V, Young M C, Kato M J, Furlan M

机构信息

Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900, Araraquara-SP, Brazil.

出版信息

J Nat Prod. 1998 May;61(5):637-9. doi: 10.1021/np9703656.

DOI:10.1021/np9703656

PMID:9599264

Abstract

Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3', 4'-methylenedioxyphenyl)-2(E)-pentadienoyl] pyrrolidine and N-[2-(3', 4'-methylenedioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES-MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.

摘要

对胡椒科多毛胡椒叶片的二氯甲烷提取物进行生物活性导向分离，除得到两种已知酰胺N-[5-(3',4'-亚甲二氧基苯基)-2(E)-戊二烯酰基]吡咯烷和N-[2-(3',4'-亚甲二氧基-6'-甲氧基苯基)-2(Z)-丙烯酰基]吡咯烷外，还得到一种新的吡咯烷酰胺N-[7-(3',4'-亚甲二氧基苯基)-2(Z),4(Z)-庚二烯酰基]吡咯烷1。通过对包括电喷雾质谱在内的光谱数据进行解析，阐明了化合物1的结构。化合物1对球孢枝孢菌显示出抗真菌活性。