Wiwanitkit Viroj, Suwansaksri Jamsai, Neramitraram Piyapitch, Praneesrisawasdi Phubate
Department of Laboratory Medicine, Faculty of Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Biomarkers. 2003 May-Aug;8(3-4):339-42. doi: 10.1080/1354750031000066199.
Benzene is a common toxic volatile substance associated with many industrial processes. Benzene exposure is of particular concern because recent research indicates that it can result in chronic toxicity and thousands of workers in industrial plants experience ongoing exposure. Therefore, the determination and control of benzene exposure among at-risk workers is very important. Urinary trans,trans-muconic acid (ttMA) determination is a helpful test for monitoring groups of at-risk workers for exposure to benzene. In this study, 103 urine samples were obtained from 60 controls and 43 occupational exposed press workers in a press factory in Bangkok. All samples were analysed for ttMA using a previously reported method. The average urinary ttMA levels for the control and exposed groups were 0.08+/-0.03 mg g(-1) creatinine and 0.56+/-0.65 mg g(-1) creatinine, respectively. Significantly higher urinary ttMA levels were observed among the press workers (p=0.03). The introduction of public health policies concerning the prevention of exposure to benzene among at-risk workers is recommended, and more widespread use of biological monitoring for the assessment and control of occupational exposure to industrial chemicals is encouraged.
苯是一种与许多工业过程相关的常见有毒挥发性物质。苯暴露备受关注，因为最近的研究表明它会导致慢性毒性，并且工厂中有数千名工人持续暴露于苯。因此，确定和控制高危工人的苯暴露非常重要。尿中反式、反式粘康酸（ttMA）测定是监测高危工人苯暴露情况的一项有用检测。在本研究中，从曼谷一家冲压厂的60名对照者和43名职业暴露冲压工人那里获取了103份尿液样本。所有样本均采用先前报道的方法分析ttMA。对照组和暴露组的尿ttMA平均水平分别为0.08±0.03毫克/克肌酐和0.56±0.65毫克/克肌酐。冲压工人的尿ttMA水平显著更高（p = 0.03）。建议出台有关预防高危工人苯暴露的公共卫生政策，并鼓励更广泛地使用生物监测来评估和控制职业性工业化学品暴露。
