Tufano M A, Cipollaro de l'Ero G, Ianniello R, Baroni A, Galdiero F
Institute of Microbiology, First Medical School, University of Naples, Italy.
Immunopharmacol Immunotoxicol. 1992;14(4):769-82. doi: 10.3109/08923979209009234.
Evaluation was carried out on the action of different antibiotics on the release of cytokines. Experiments were done in vitro on monocytes and on human lymphocytes. Results show that the majority of the antibiotics tested are able to induce the release of one or more cytokines from their respective producing cells. Among the beta-lactams the most active were the cephalosporins (cephalexin, cefamandol, ceftazidin, and a sulbactam-ampicillin combination) in inducing the release of TNF, IL-1 alpha, and IL-6 from monocytes, and releasing IL-4 and IFN-tau from lymphocytes. The sulbactam-ampicillin combination and cefamandole were extremely active in the production of IFN-tau. Among the lincosamides, clindamycine notably stimulated the release of TNF and IL-6, while lincomycine induced a notable increment of IL-4 from monocytes. Teicoplanin is a very strong inducer of TNF, IL-1 alpha and IL-6.
对不同抗生素对细胞因子释放的作用进行了评估。实验在体外对单核细胞和人淋巴细胞进行。结果表明，大多数测试抗生素能够诱导各自产生细胞释放一种或多种细胞因子。在β-内酰胺类抗生素中，头孢菌素（头孢氨苄、头孢孟多、头孢他啶以及舒巴坦-氨苄西林组合）在诱导单核细胞释放TNF、IL-1α和IL-6以及淋巴细胞释放IL-4和IFN-τ方面最为活跃。舒巴坦-氨苄西林组合和头孢孟多在IFN-τ的产生方面极其活跃。在林可酰胺类抗生素中，克林霉素显著刺激TNF和IL-6的释放，而林可霉素诱导单核细胞中IL-4显著增加。替考拉宁是TNF、IL-1α和IL-6的非常强的诱导剂。
