Tamm Lukas K, Crane Jonathan, Kiessling Volker
Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA.
Curr Opin Struct Biol. 2003 Aug;13(4):453-66. doi: 10.1016/s0959-440x(03)00107-6.
The fusion of biological membranes is governed by the carefully orchestrated interplay of membrane proteins and lipids. Recently determined structures of fusion proteins, individual domains of fusion proteins and their complexes with regulatory proteins and membrane lipids have yielded much suggestive insight into how viral and intracellular membrane fusion might proceed. These structures may be combined with new knowledge on the fusion of pure lipid bilayer membranes in an attempt to begin to piece together the complex puzzle of how biological membrane fusion machines operate on membranes.
生物膜的融合由膜蛋白和脂质精心编排的相互作用所控制。最近确定的融合蛋白结构、融合蛋白的各个结构域及其与调节蛋白和膜脂质的复合物，为病毒和细胞内膜融合的可能过程提供了许多有启发性的见解。这些结构可以与关于纯脂质双分子层膜融合的新知识相结合，试图开始拼凑出生物膜融合机制如何在膜上运作的复杂谜题。
