Björnsdottir Unnur Steina, Jakobinudottir Sigridur, Runarsdottir Valgerdur, Juliusson Sigurdur
Health Care Center, Reykjavik, Iceland.
Ann Allergy Asthma Immunol. 2003 Aug;91(2):189-94. doi: 10.1016/s1081-1206(10)62176-x.
Treatment of cat allergy normally entails removal of the cat from the household, but cat owners are often unwilling to part with their pets, despite clinically relevant allergies.
To determine whether levels of Fel d 1 can be reduced without removal of the cat and whether this will affect symptoms of cat allergy.
Cat-allergic patients underwent randomization to either a group instructed in environmental control (EC) and a group with unchanged environment (UE). Dust samples were obtained and settled Fel d 1 measured by enzyme-linked immunosorbent assay. Patients recorded daily nasal inspiratory flow rates. At baseline, 3 months, and 8 months, patients underwent symptom evaluation.
Eighteen patients were randomized to the EC group and 22 to the UE group; the final number completing the study was 31, 15 in the EC group, and 16 in the UE group. At 8 months, home Fel d 1 levels had diminished to 6.8% of baseline levels in the EC group, whereas no reduction in levels was noted in the UE group. In the EC group, significant improvements were found in nasal inspiratory flow rate and symptoms compared with the UE group. Patients did not have difficulties adhering to EC measures.
A decrease in the allergen load was found in the EC group, which had a significant effect on symptoms of nasal allergy.
猫过敏的治疗通常需要将猫移出家庭，但尽管存在临床相关过敏，猫主人往往不愿意与他们的宠物分开。
确定在不移走猫的情况下，猫过敏原1（Fel d 1）水平是否可以降低，以及这是否会影响猫过敏症状。
将猫过敏患者随机分为接受环境控制指导的组（EC组）和环境不变的组（UE组）。采集灰尘样本，通过酶联免疫吸附测定法测量沉降的Fel d 1。患者记录每日鼻吸气流量。在基线、3个月和8个月时，对患者进行症状评估。
18例患者被随机分配到EC组，22例被分配到UE组；完成研究的最终人数为31例，其中EC组15例，UE组16例。在8个月时，EC组家中的Fel d 1水平降至基线水平的6.8%，而UE组未观察到水平降低。与UE组相比，EC组的鼻吸气流量和症状有显著改善。患者在坚持环境控制措施方面没有困难。
在EC组中发现过敏原负荷降低，这对鼻过敏症状有显著影响。
