常规治疗失败后用于梅尼埃病的自由基清除剂：一项初步研究。
Radical scavengers for Ménière's disease after failure of conventional therapy: a pilot study.
作者信息
Takumida Masaya, Anniko Matti, Ohtani Makiko
机构信息
Department of Otolaryngology, Hiroshima University School of Medicine, Hiroshima, Japan.
出版信息
Acta Otolaryngol. 2003 Aug;123(6):697-703. doi: 10.1080/00016480310000728a.
OBJECTIVE
To perform a trial to assess the efficacy of radical scavengers, i.e. rebamipide, vitamin C and glutathione, for the treatment of Ménière's disease (MD).
MATERIAL AND METHODS
Rebamipide (300 mg/day), vitamin C (600 mg/day) and/or glutathione (300 mg/day) were given orally for at least 8 weeks to 25 patients with poorly controlled MD.
RESULTS
Of 22 patients, 21 showed marked improvement of vertigo; 12/27 ears showed improvement of hearing disorders; 17/27 ears showed improvement of tinnitus; and 18/25 patients showed improvement of disability.
CONCLUSION
This study suggests that treatment using radical scavengers has the potential to become an effective new therapy for MD.
目的
进行一项试验，以评估自由基清除剂，即瑞巴派特、维生素C和谷胱甘肽治疗梅尼埃病（MD）的疗效。
材料与方法
对25例MD控制不佳的患者口服瑞巴派特（300毫克/天）、维生素C（600毫克/天）和/或谷胱甘肽（300毫克/天）至少8周。
结果
22例患者中，21例眩晕明显改善；27只耳中有12只耳听力障碍改善；27只耳中有17只耳耳鸣改善；25例患者中有18例残疾状况改善。
结论
本研究表明，使用自由基清除剂进行治疗有可能成为MD的一种有效的新疗法。
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