Isomaa Bo
Department of Internal Medicine, Jakobstad Hospital, PB 23, 68601, Jakobstad, Finland.
Life Sci. 2003 Sep 26;73(19):2395-411. doi: 10.1016/s0024-3205(03)00646-5.
The clustering of several metabolic and cardiovascular disease risk factors has been termed the metabolic syndrome. The metabolic syndrome seems to result from a collision between susceptible "thrifty genes" and a society characterized by an increased prevalence of obesity and a sedentary lifestyle. The typical patient is characterized by abdominal obesity, a varying degree of glucose intolerance, dyslipidemia and often hypertension. The components of the metabolic syndrome are associated with insulin resistance, disturbances of coagulation and fibrinolysis, endothelial dysfunction and elevated markers of sub-clinical inflammation. The current review focuses mainly on the new definitions of the syndrome, the results of recent epidemiological studies and the consequences of the metabolic syndrome as an important risk factor for cardiovascular disease, premature death and diabetes. The metabolic syndrome constitutes a major challenge for public health professionals in the field of preventive medicine since more than 40 million U.S. adults seem to be affected by the syndrome. Lifestyle changes could have a profound influence on the syndrome and its development.
几种代谢和心血管疾病风险因素的聚集被称为代谢综合征。代谢综合征似乎是由易感性“节俭基因”与一个以肥胖患病率增加和久坐生活方式为特征的社会之间的碰撞所导致的。典型患者的特征是腹部肥胖、不同程度的葡萄糖不耐受、血脂异常，且常伴有高血压。代谢综合征的各组成部分与胰岛素抵抗、凝血和纤维蛋白溶解紊乱、内皮功能障碍以及亚临床炎症标志物升高有关。本综述主要关注该综合征的新定义、近期流行病学研究结果以及代谢综合征作为心血管疾病、过早死亡和糖尿病的重要风险因素所带来的后果。代谢综合征对预防医学领域的公共卫生专业人员构成了重大挑战，因为美国似乎有超过4000万成年人受该综合征影响。生活方式的改变可能会对该综合征及其发展产生深远影响。
