Windisch Wolfram, Freidel Klaus, Schucher Bernd, Baumann Hansjörg, Wiebel Matthias, Matthys Heinrich, Petermann Franz
Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, D-79106 Freiburg, Germany.
J Clin Epidemiol. 2003 Aug;56(8):752-9. doi: 10.1016/s0895-4356(03)00088-x.
The objective of this study was to develop a specific instrument for measuring health-related quality of life (HRQL) in patients receiving home mechanical ventilation (HMV).
The Severe Respiratory Insufficiency (SRI) Questionnaire was developed and tested for its psychometric properties following a multicentric clinical trial including 226 patients receiving HMV (mean age 57.3+/-14.0 years).
Forty-nine items passed the selection process and were allocated to seven subscales: Respiratory Complaints, Physical Functioning, Attendant Symptoms and Sleep, Social Relationships, Anxiety, Psychologic Well-Being, and Social Functioning. Cronbach's alpha was >0.7 in all subscales and >0.8 in four subscales indicating high internal consistency reliability. Construct validity was confirmed by factor analysis, indicating one summary scale that accounts for 59.8% of the variance. Concurrent validity was confirmed by correlating subscales of the SRI and the SF-36 (0.21<r<0.79). Item-scale correlations revealed a high item discriminant validity. In addition, different diagnostic groups could be discriminated by the SRI. Here, the overall best HRQL was measured in the following order: patients with kyphoscoliosis, miscellaneous disorders, neuromuscular diseases, post-tuberculosis, and chronic obstructive pulmonary disease (P<.05).
The SRI is a new multidimensional instrument with high psychometric properties designed to measure specific HRQL in patients with SRI receiving HMV.
本研究的目的是开发一种用于测量接受家庭机械通气（HMV）患者健康相关生活质量（HRQL）的特定工具。
在一项多中心临床试验中，对226例接受HMV的患者（平均年龄57.3±14.0岁）开发并测试了严重呼吸功能不全（SRI）问卷的心理测量特性。
49个项目通过筛选过程，并被分配到7个分量表：呼吸症状、身体功能、伴随症状与睡眠、社会关系、焦虑、心理健康和社会功能。所有分量表的Cronbach's α均>0.7，4个分量表>0.8，表明内部一致性可靠性高。通过因子分析证实了结构效度，表明一个汇总量表解释了59.8%的方差。通过将SRI和SF-36的分量表进行相关性分析（0.21<r<0.79）证实了同时效度。项目-量表相关性显示出较高的项目区分效度。此外，SRI可以区分不同的诊断组。在此，按以下顺序测量出总体最佳HRQL：脊柱后凸畸形患者、其他疾病患者、神经肌肉疾病患者、肺结核后患者和慢性阻塞性肺疾病患者（P<.05）。
SRI是一种新的多维工具，具有较高的心理测量特性，旨在测量接受HMV的SRI患者的特定HRQL。
