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[紫外线辐射及其他环境危害导致的皮肤过早衰老。分子基础]

[Premature skin aging by ultraviolet radiation and other environmental hazards. The molecular basis].

作者信息

Krutmann J

机构信息

Institut für Umweltmedizinische Forschung an der Heinrich-Heine-Universität gGmbH, Düsseldorf.

出版信息

Hautarzt. 2003 Sep;54(9):809-17. doi: 10.1007/s00105-003-0575-5.

DOI:10.1007/s00105-003-0575-5
PMID:12955256
Abstract

The study of the molecular basis of aging is becoming increasingly important for environmental and dermatological research. In addition to ultraviolet radiation, there are other environmental influences which play a significant role in premature aging processes of the human skin. These include tobacco smoke and, according to recent results, also infrared radiation, ozone and other environmental hazards. Based on our current understanding of the molecular biological basis of the effects of environmental hazards, this overview aims at listing the most important findings which contribute to aging of the skin.

摘要

衰老的分子基础研究对于环境和皮肤病学研究而言正变得愈发重要。除紫外线辐射外,还有其他环境因素在人类皮肤过早衰老过程中发挥着重要作用。这些因素包括烟草烟雾,而且根据最近的研究结果,还包括红外线辐射、臭氧及其他环境危害。基于我们目前对环境危害影响的分子生物学基础的理解,本综述旨在列出有助于皮肤衰老的最重要研究发现。

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本文引用的文献

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Stability of the nuclear protein turnover during cellular senescence of human fibroblasts.人成纤维细胞细胞衰老过程中核蛋白周转的稳定性
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Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts.红外线A辐射诱导的基质金属蛋白酶1表达是通过人皮肤成纤维细胞中细胞外信号调节激酶1/2的激活介导的。
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日光的阴暗面:光老化与黑色素瘤进展中的肿瘤微环境。
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在转基因小鼠表皮中靶向过表达血管生成抑制剂血小板反应蛋白-1可预防紫外线B诱导的血管生成和皮肤光损伤。
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Ozone: an emerging oxidative stressor to skin.臭氧:一种新兴的皮肤氧化应激源。
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Photoaging of human skin.人类皮肤的光老化
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Alterations of extracellular matrix induced by tobacco smoke extract.烟草烟雾提取物诱导的细胞外基质改变。
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8
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Pathophysiology of premature skin aging induced by ultraviolet light.紫外线诱导的皮肤过早老化的病理生理学
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10
Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system.与未暴露于紫外线的皮肤及造血系统相比,长期暴露于紫外线的人体皮肤显示出线粒体DNA更高的突变频率。
Photochem Photobiol. 1997 Aug;66(2):271-5. doi: 10.1111/j.1751-1097.1997.tb08654.x.