From the Integrative Center for Aging Research, O'Neal Comprehensive Cancer Center, Department of Genetics, UAB School of Medicine, University of Alabama at Birmingham.
Plast Reconstr Surg. 2021 Jan 1;147(1S-2):33S-37S. doi: 10.1097/PRS.0000000000007619.
The genetic basis of youthfulness is poorly understood. The aging of skin depends on both intrinsic factors and extrinsic factors. Intrinsic factors include personal genetics, and extrinsic factors include environmental exposure to solar radiation and pollution. We recently reported the critical role of the mitochondria in skin aging phenotypes: wrinkle formation, hair graying, hair loss, and uneven skin pigmentation. This article focuses on molecular mechanisms, specifically mitochondrial mechanisms underlying skin aging. This contribution describes the development of an mitochondrial DNA depleter-repleter mouse model and its usefulness in developing strategies and identifying potential agents that can either prevent, slow, or mitigate skin aging, lentigines, and hair loss. The ongoing research efforts include the transplantation of young mitochondria to rejuvenate aging skin and hair to provide youthfulness in humans.
青春的遗传学基础尚未被完全理解。皮肤老化既取决于内在因素，也取决于外在因素。内在因素包括个人遗传，外在因素包括暴露于太阳辐射和污染的环境中。我们最近报道了线粒体在皮肤老化表型中的关键作用：皱纹形成、头发变白、脱发和皮肤色素不均匀。本文重点介绍皮肤老化的分子机制，特别是线粒体机制。本文介绍了一种线粒体 DNA 耗竭剂-补充剂小鼠模型的开发及其在制定策略和识别潜在药物方面的用途，这些药物可以预防、减缓或减轻皮肤老化、老年斑和脱发。正在进行的研究工作包括将年轻的线粒体移植到老化的皮肤和头发中，以恢复人类的青春。
