Schieke Stefan M, Schroeder Peter, Krutmann Jean
Institut fuer Umweltmedizinische Forschung (IUF) an der Heinrich-Heine-Universitaet gGmbH, Auf'm Hennekamp 50, D-40225 Duesseldorf, Germany.
Photodermatol Photoimmunol Photomed. 2003 Oct;19(5):228-34. doi: 10.1034/j.1600-0781.2003.00054.x.
Human skin is exposed to infrared (IR) radiation (760 nm-1 mm) from natural as well as artificial sources that are increasingly used for cosmetic or medical purposes. Epidemiological data and clinical observations, however, indicate that IR radiation cannot be considered as totally innocuous to human skin. In particular, IR radiation, similar to ultraviolet radiation, seems to be involved in photoaging and potentially also in photocarcinogenesis. The molecular consequences resulting from IR exposure are virtually unknown. Recent studies, however, have begun to shed light on the basic molecular processes such as cellular signal transduction and gene expression triggered by exposure to IR radiation. In response to IR irradiation, mitogen-activated protein kinase signaling pathways were activated mediating the upregulation of matrix metalloproteinase-1 expression. This previously unrecognized molecular 'IR response' shows that IR radiation is capable of specifically interfering with cellular functions and provides a molecular basis for biological effects of IR on human skin.
人类皮肤会暴露于来自自然以及人工来源的红外（IR）辐射（760纳米 - 1毫米），这些来源越来越多地用于美容或医疗目的。然而，流行病学数据和临床观察表明，IR辐射不能被视为对人类皮肤完全无害。特别是，IR辐射与紫外线辐射类似，似乎与光老化有关，并且可能也与光致癌作用有关。IR暴露所导致的分子后果实际上尚不清楚。然而，最近的研究已经开始揭示诸如细胞信号转导和由IR辐射暴露引发的基因表达等基本分子过程。响应于IR照射，丝裂原活化蛋白激酶信号通路被激活，介导基质金属蛋白酶 - 1表达的上调。这种先前未被认识的分子“IR反应”表明，IR辐射能够特异性地干扰细胞功能，并为IR对人类皮肤的生物学效应提供了分子基础。
