严重急性呼吸综合征患者淋巴细胞及淋巴细胞亚群的表达
Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome.
作者信息
Cui Wei, Fan Ying, Wu Wei, Zhang Feng, Wang Jun-ying, Ni An-ping
机构信息
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.
出版信息
Clin Infect Dis. 2003 Sep 15;37(6):857-9. doi: 10.1086/378587. Epub 2003 Aug 28.
Abstract
In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4(+) T lymphocyte levels were reduced in 100% of patients, CD8(+) T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.
摘要
在一组38例严重急性呼吸综合征（SARS）患者中，我们观察到47%的患者出现白细胞减少，84%的患者出现淋巴细胞减少，95%的患者出现T淋巴细胞减少。100%的患者CD4(+) T淋巴细胞水平降低，87%的患者CD8(+) T淋巴细胞水平降低，76%的患者B淋巴细胞水平降低，55%的患者自然杀伤细胞水平降低。我们的数据表明，这些患者的免疫系统在SARS病程中受到损害。淋巴细胞亚群的绝对计数对SARS患者具有临床意义。
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