Karakurum Gunhan, Buyukbebeci Orhan, Kalender Murat, Gulec Akif
Department of Orthopaedics and Traumatology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey.
J Surg Res. 2003 Aug;113(2):195-200. doi: 10.1016/s0022-4804(03)00204-x.
Hyaluronic acid and its derivatives have become increasingly popular for preventing adhesions in primary tendon repair. Their use in tenolysis, however, has not been established yet. The purpose of the current study was to evaluate the efficacy of Seprafilm, a combination of carboxymethylcellulose membrane and hyaluronate, in prevention of adhesion formation after tenolysis.
Thirty chickens were initially operated on their right central toes in order to constitute an experimental setting of postoperative flexor tendon adhesion. They were then randomly assigned to 3 groups at 6 weeks. Group 1 received no further procedure, group 2 underwent simple tenolysis with physiologic saline injection, and group 3 had tenolysis with Seprafilm interposition.
Group 3 scored a significantly higher average gliding excursion value than the other groups. Histologic examination corroborated the biomechanical data.
Seprafilm was effective in preventing adhesions after tenolysis.
透明质酸及其衍生物在原发性肌腱修复中预防粘连的应用越来越广泛。然而，它们在肌腱松解术中的应用尚未得到证实。本研究的目的是评估羧甲基纤维素膜和透明质酸盐组合的Seprafilm在肌腱松解术后预防粘连形成的疗效。
最初对30只鸡的右中趾进行手术，以构建术后屈肌腱粘连的实验模型。6周时，将它们随机分为3组。第1组不进行进一步手术，第2组进行单纯肌腱松解并注射生理盐水，第3组进行肌腱松解并置入Seprafilm。
第3组的平均滑动偏移值明显高于其他组。组织学检查证实了生物力学数据。
Seprafilm在肌腱松解术后预防粘连有效。
