Schofield K P, Voulgari F, Gozzard D I, Leyland M J, Beeching N J, Stuart J
J Clin Pathol. 1982 Aug;35(8):866-9. doi: 10.1136/jcp.35.8.866.
Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.
采用一小时激光免疫比浊法，对22例急性白血病中性粒细胞减少患者的29次感染发作进行血清C反应蛋白（CRP）浓度的连续监测。在所有29次感染发作中，血清CRP均升高至诊断水平100mg/L以上，并持续逐渐上升，直至给予适当的抗生素或粒细胞后，其以约三天的半衰期下降。血清浓度的连续研究对于检测隐匿性或未解决的细菌感染具有价值，并提供了一种监测对抗生素和粒细胞治疗反应的客观方法。
