C反应蛋白浓度作为急性白血病抗生素治疗的指导指标
C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
作者信息
Schofield K P, Voulgari F, Gozzard D I, Leyland M J, Beeching N J, Stuart J
出版信息
J Clin Pathol. 1982 Aug;35(8):866-9. doi: 10.1136/jcp.35.8.866.
Abstract
Serial monitoring of the serum C-reactive protein (CRP) concentration was performed, using a one-hour laser-immunonephelometric assay, during 29 episodes of infection in 22 neutropenic patients with acute leukaemia. Serum CRP increased to above a diagnostic level of 100 mg/l in all 29 episodes and continued to rise progressively until appropriate antibiotics, or granulocytes, were given when it fell with a half-life of approximately three days. Serial study of the serum concentration was of value in detecting occult or unresolved bacterial infection and provided an objective means of monitoring the response to antibiotic and granulocyte therapy.
摘要
采用一小时激光免疫比浊法，对22例急性白血病中性粒细胞减少患者的29次感染发作进行血清C反应蛋白（CRP）浓度的连续监测。在所有29次感染发作中，血清CRP均升高至诊断水平100mg/L以上，并持续逐渐上升，直至给予适当的抗生素或粒细胞后，其以约三天的半衰期下降。血清浓度的连续研究对于检测隐匿性或未解决的细菌感染具有价值，并提供了一种监测对抗生素和粒细胞治疗反应的客观方法。
相似文献
1
C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia.
J Clin Pathol. 1982 Aug;35(8):866-9. doi: 10.1136/jcp.35.8.866.
2
Serial study of C-reactive protein during infection in leukaemia.
J Clin Pathol. 1981 Mar;34(3):263-6. doi: 10.1136/jcp.34.3.263.
3
C-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukaemia.
Eur J Cancer Clin Oncol. 1985 May;21(5):557-62. doi: 10.1016/0277-5379(85)90080-x.
4
Serum C-reactive protein levels in the management of infection in acute leukaemia.
Eur J Cancer Clin Oncol. 1984 Mar;20(3):319-25. doi: 10.1016/0277-5379(84)90076-2.
5
C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia.
Clin Infect Dis. 1994 Apr;18(4):589-95. doi: 10.1093/clinids/18.4.589.
6
Infections in acute leukaemia.
J Assoc Physicians India. 1992 Jan;40(1):36-9.
7
The management of febrile episodes in-neutropenic cancer.
Med J Aust. 1977 Apr 2;1(14):473-5.
8
Asymptomatic C-reactive protein elevation in neutropenic children.
Pediatr Int. 2017 Jan;59(1):23-28. doi: 10.1111/ped.13077. Epub 2016 Sep 21.
9
Granulocyte transfusions as a therapy and a prophylaxis of infections in neutropenic patients.
Eur J Cancer (1965). 1979;15 Suppl:15-22.
10
[C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis].
Srp Arh Celok Lek. 2001 May-Jun;129 Suppl 1:17-22.
引用本文的文献
1
Haptoglobin in Juvenile Idiopathic Arthritis.
Pediatr Rheumatol Online J. 2022 Dec 15;20(1):117. doi: 10.1186/s12969-022-00777-5.
2
Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients.
BMC Cancer. 2020 Mar 24;20(1):249. doi: 10.1186/s12885-020-06754-z.
3
C-reactive protein and alpha 1-acid glycoprotein levels in dogs infected with Ehrlichia canis.
J Clin Microbiol. 1994 Apr;32(4):912-7. doi: 10.1128/jcm.32.4.912-917.1994.
4
C-reactive protein as an indicator of resolution of sepsis in the intensive care unit.
Intensive Care Med. 1995 Jul;21(7):602-5. doi: 10.1007/BF01700168.
5
C-reactive protein in patients with bacteremia.
J Clin Microbiol. 1984 Sep;20(3):317-9. doi: 10.1128/jcm.20.3.317-319.1984.
6
C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients.
J Clin Pathol. 1984 Jul;37(7):821-5. doi: 10.1136/jcp.37.7.821.
7
Value of serum C-reactive protein measurement in the management of bone marrow transplant recipients. Part I: Early transplant period.
J Clin Pathol. 1984 Sep;37(9):1018-21. doi: 10.1136/jcp.37.9.1018.
8
Measurement of serum C reactive protein concentration after bone marrow transplantation for leukaemia.
J Clin Pathol. 1984 Mar;37(3):263-6. doi: 10.1136/jcp.37.3.263.
9
C reactive protein in the evaluation of febrile illness.
Arch Dis Child. 1986 Jan;61(1):24-9. doi: 10.1136/adc.61.1.24.
10
Serial concentrations of C-reactive protein as an indicator of urinary tract infection in patients with spinal injury.
J Clin Pathol. 1986 Aug;39(8):851-5. doi: 10.1136/jcp.39.8.851.
本文引用的文献
1
Efficiency of haematological screening tests for detecting disease.
Clin Lab Haematol. 1981;3(4):299-305.
2
Serial study of C-reactive protein during infection in leukaemia.
J Clin Pathol. 1981 Mar;34(3):263-6. doi: 10.1136/jcp.34.3.263.
3
Granulocyte transfusions: where now?
N Engl J Med. 1981 Sep 10;305(11):636-8. doi: 10.1056/NEJM198109103051109.
4
C-reactive protein fifty years on.
Lancet. 1981 Mar 21;1(8221):653-7. doi: 10.1016/s0140-6736(81)91565-8.
5
Rabbit CRP response to endotoxin administration: dose-response relationship and kinetics.
Proc Soc Exp Biol Med. 1974 Sep;146(4):1132-6. doi: 10.3181/00379727-146-38260.
6
The liver as the site of C-reactive protein formation.
J Exp Med. 1966 Feb 1;123(2):365-78. doi: 10.1084/jem.123.2.365.
Zotero 插件