Kirilenko N P, Paramonova I V
Gematol Transfuziol. 1992 Nov-Dec;37(11-12):20-3.
Red blood cell membrane lipid composition was studied in 51 iron deficiency anemia patients, in 10 of them during ferro-therapy. It was noted that red blood cell membranes contained increased total levels of lipids, phospholipids and significantly decreased levels of cholesterol esters and lysophospholipids. During the treatment, in the presence of a distinct process of the recovery of disturbed lipid composition of red blood cell membranes, a significant increase was recorded in the content of triglycerides, phosphatidyl amines, while phosphatidyl and cardiolipin levels were significantly lowered. Red blood cell membrane lipid content in iron deficiency anemia patients and its dynamics in the process of their treatment might serve as an additional criteria of the body saturation with iron.
对51例缺铁性贫血患者的红细胞膜脂质成分进行了研究，其中10例在铁剂治疗期间进行了研究。结果发现，红细胞膜中的脂质、磷脂总量增加，而胆固醇酯和溶血磷脂水平显著降低。在治疗过程中，随着红细胞膜紊乱脂质成分明显恢复，甘油三酯、磷脂酰胺含量显著增加，而磷脂酰胆碱和心磷脂水平显著降低。缺铁性贫血患者红细胞膜脂质含量及其治疗过程中的动态变化可能作为机体铁饱和度的附加标准。
