Kirilenko N P, Paramonova I V
Gematol Transfuziol. 1990 Jul;35(7):18-20.
The assay of lipid composition in red blood cells of 51 patients with iron-deficiency anemia (IDA) was conducted with the use of horizontal thin-layer chromatography, and the state of the end blood flow was studied with the ai of conjunctival biomicroscopy. It was found that in IDA patients the content of total lipids, phospholipids, free fatty acids, cholesterol, sphingomyelins, cardiolipins and phosphatidic acids increased and that of triglycerides decreased. The content of the rest fractions of total lipids in IDA patients was practically not changed. Variations in lipid composition of red blood cells lead to disorders in their functional activity. In IDA patients it is clinically expressed in the development of the sludge phenomenon that aggravates tissue hypoxia in women with this disease.
采用水平薄层色谱法对51例缺铁性贫血（IDA）患者红细胞中的脂质成分进行了分析，并借助结膜生物显微镜研究了末梢血流状态。结果发现，IDA患者的总脂质、磷脂、游离脂肪酸、胆固醇、鞘磷脂、心磷脂和磷脂酸含量增加，而甘油三酯含量降低。IDA患者总脂质其余组分的含量实际上未发生变化。红细胞脂质成分的改变会导致其功能活动紊乱。在IDA患者中，这在临床上表现为出现淤滞现象，加重了该病女性患者的组织缺氧。
