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2-巯基苯磺酰胺的衍生物。VIII. 1,3-二烷基-2-(4-氯-2-羧基烷硫基-5-甲基苯磺酰基)胍的合成及某些药理性质

Derivatives of 2-mercaptobenzenesulphonamide. VIII. Synthesis and some pharmacological properties of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl) guanidines.

作者信息

Brzozowski Z, Sławiński J, Filczewski M, Szymańska-Kosmala M, Miłobedzka J, Oledzka K

机构信息

Department of Drug Technology, School of Medicine, 107 K. Marksa Str., 80-416 Gdańsk, Poland.

出版信息

Acta Pol Pharm. 1990;47(1-2):57-63.

PMID:12959261
Abstract

Synthesis of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl)guanidines (IX-XVII) and their easily soluble in water sodium (Xa-XIVa, XVIIa) or 2,6-dimethylpiperidine salts (XIb, XVIIb) have been described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system have been presented.

摘要

已描述了1,3 - 二烷基 - 2 -（4 - 氯 - 2 - 羧基烷基硫代 - 5 - 甲基苯磺酰基）胍（IX - XVII）及其易溶于水的钠盐（Xa - XIVa，XVIIa）或2,6 - 二甲基哌啶盐（XIb，XVIIb）的合成。还给出了初步药理检查的结果，如急性毒性和对循环系统的影响。

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