Hill Dina E, Yeo Ronald A, Campbell Richard A, Hart Blaine, Vigil Janet, Brooks William
Center for Neuropsychological Services, Department of Psychiatry, Albuquerque 87131, USA.
Neuropsychology. 2003 Jul;17(3):496-506. doi: 10.1037/0894-4105.17.3.496.
This study compared magnetic resonance imaging size differences in several brain regions and neurocognitive function in a group of male and female children with attention-deficit/hyperactivity disorder (ADHD) with no comorbid learning disorders with a normal control group of children. The ADHD group demonstrated smaller total brain, superior prefrontal, and right superior prefrontal volumes, as well as significantly smaller areas for cerebellar lobules I-V and VIII-X, total corpus callosum area, and splenium. No group differences were observed for the inferior prefrontal, caudate, or cerebellar volumes, or for the area of cerebellar lobules VI-VII. In the ADHD group but not in the control group, greater right superior prefrontal volume predicted poorer performance on a test of sustained attention. Patterns of brain abnormality did not differ in male and female children with ADHD.
本研究比较了一组患有注意力缺陷多动障碍（ADHD）且无合并学习障碍的男童和女童与正常对照组儿童在几个脑区的磁共振成像大小差异及神经认知功能。ADHD组的全脑、额上回和右侧额上回体积较小，小脑小叶I-V和VIII-X、胼胝体总面积和压部的面积也明显较小。额下回、尾状核或小脑体积，以及小脑小叶VI-VII的面积在两组间未观察到差异。在ADHD组而非对照组中，右侧额上回体积越大，在持续注意力测试中的表现越差。ADHD男童和女童的脑异常模式没有差异。
