Rosenkranz Melissa A, Jackson Daren C, Dalton Kim M, Dolski Isa, Ryff Carol D, Singer Burt H, Muller Daniel, Kalin Ned H, Davidson Richard J
Laboratory for Affective Neuroscience, Department of Psychology, University of Wisconsin, 1202 W. Johnson Street, Madison, WI 53706, USA.
Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11148-52. doi: 10.1073/pnas.1534743100. Epub 2003 Sep 5.
Considerable evidence exists to support an association between psychological states and immune function. However, the mechanisms by which such states are instantiated in the brain and influence the immune system are poorly understood. The present study investigated relations among physiological measures of affective style, psychological well being, and immune function. Negative and positive affect were elicited by using an autobiographical writing task. Electroencephalography and affect-modulated eye-blink startle were used to measure trait and state negative affect. Participants were vaccinated for influenza, and antibody titers after the vaccine were assayed to provide an in vivo measure of immune function. Higher levels of right-prefrontal electroencephalographic activation and greater magnitude of the startle reflex reliably predicted poorer immune response. These data support the hypothesis that individuals characterized by a more negative affective style mount a weaker immune response and therefore may be at greater risk for illness than those with a more positive affective style.
有大量证据支持心理状态与免疫功能之间存在关联。然而，人们对这些状态在大脑中是如何形成并影响免疫系统的机制知之甚少。本研究调查了情感风格的生理指标、心理健康与免疫功能之间的关系。通过一项自传体写作任务来引发消极和积极情绪。使用脑电图和情感调节眨眼惊跳反应来测量特质性和状态性消极情绪。参与者接种了流感疫苗，并检测疫苗接种后的抗体滴度，以提供免疫功能的体内测量指标。右侧前额叶脑电图激活水平较高和惊跳反射幅度较大可靠地预测了较差的免疫反应。这些数据支持了这样一种假设，即具有更消极情感风格的个体免疫反应较弱，因此与具有更积极情感风格的个体相比，患病风险可能更高。
