Serra Salvatore, Vacca Giovanni, Tumatis Silvia, Carrucciu Angela, Morazzoni Paolo, Bombardelli Ezio, Colombo Giancarlo, Gessa Gian Luigi, Carai Mauro A M
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy.
J Ethnopharmacol. 2003 Oct;88(2-3):249-52. doi: 10.1016/s0378-8741(03)00260-5.
Salvia miltiorrhiza extracts have been reported to suppress acquisition and maintenance of alcohol drinking behavior in Sardinian alcohol-preferring (sP) rats. The present study investigated whether IDN 5082, a standardized extract of Salvia miltiorrhiza, was capable of preventing, in sP rats, the development of the so-called alcohol deprivation effect (ADE), i.e. the transient increase in alcohol intake that occurs in laboratory animals after a period of alcohol deprivation. Interestingly, ADE has been proposed to model alcohol relapses in human alcoholics. The acute, intragastric administration of 25, 50, and 100 mg/kg IDN 5082 resulted in the complete suppression of the extra amount of alcohol consumed during the first hour of re-access to alcohol after 7 days of deprivation. These results suggest that IDN 5082 may possess anti-relapse properties.
据报道，丹参提取物可抑制撒丁岛嗜酒（sP）大鼠酒精饮用行为的习得和维持。本研究调查了丹参标准化提取物IDN 5082是否能够预防sP大鼠出现所谓的酒精戒断效应（ADE），即实验动物在一段时间的酒精剥夺后酒精摄入量的短暂增加。有趣的是，有人提出ADE可模拟人类酗酒者的酒精复吸。急性胃内给予25、50和100 mg/kg的IDN 5082可完全抑制剥夺7天后重新接触酒精后第一小时内额外摄入的酒精量。这些结果表明，IDN 5082可能具有抗复吸特性。
