Agren M S, Karlsmark T, Hansen J B, Rygaard J
Faculty of Health Sciences, University of Linköping, Sweden.
J Wound Care. 2001 Sep;10(8):301-4. doi: 10.12968/jowc.2001.10.8.26109.
The benefits of moisture-retaining dressings on wound healing are well documented in experimental animal models but not in humans. To examine the effect of occlusion, the effects of three brands of synthetic occlusive dressings (Comfeel Plus, DuoDerm CGF, OpSite) were compared with air exposure in epithelial resurfacing and proliferation in acute, full-thickness skin wounds in humans. In 10 healthy males, four 4 mm standardised wounds were made with a sterile punch biopsy on each lower extremity. Epithelialisation of the wounds was assessed histologically and blindly postwounding on days 7 and 14. Wound margin epidermal proliferation was evaluated immunohistochemically with Ki67. Epithelial percentage coverage increased significantly (p = 0.007) with the occlusive dressings (62 +/- 6%, mean +/- SEM), compared with air exposure, (39 +/- 7%) on day 7 but not on day 14 (p = 0.500). Epidermal cell proliferation showed no significant intergroup difference on either day. Treatment with occlusive dressings increased early epithelial migration of acute full-thickness biopsy wounds compared with air exposure in healthy men.
保湿敷料对伤口愈合的益处已在实验动物模型中得到充分证明，但在人类身上尚未得到证实。为了研究封闭的效果，将三种品牌的合成封闭敷料（康惠尔增强型、多爱肤CGF、优泌舒）与暴露于空气中对人类急性全层皮肤伤口上皮再形成和增殖的影响进行了比较。在10名健康男性中，在每个下肢用无菌打孔活检法制造4个4毫米的标准化伤口。在伤后第7天和第14天对伤口上皮化进行组织学评估且评估人员不知情。用Ki67免疫组化法评估伤口边缘表皮增殖情况。与暴露于空气中相比，在第7天，使用封闭敷料时上皮覆盖率显著增加（p = 0.007）（62±6%，平均值±标准误），而在第14天则无显著差异（p = 0.500）。在这两天中，表皮细胞增殖在组间均无显著差异。与健康男性暴露于空气中相比，使用封闭敷料治疗可增加急性全层活检伤口早期上皮迁移。
