de Graaf L, Diemont W L
Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH 's-Hertogenbosch, The Netherlands.
Br J Clin Pharmacol. 2003 Oct;56(4):451-2. doi: 10.1046/j.1365-2125.2003.01890.x.
To investigate the cause of chest pain during the use of bupropion as an aid to stop smoking.
The Netherlands Pharmacovigilance Centre received 22 reports of chest pain, associated with the use of bupropion as an aid to smoking cessation. Additional information about long-term follow up was collected to analyze whether these complaints herald manifest cardiac disease.
All but one patient recovered after withdrawal of bupropion. Seven patients were additionally investigated and in six of them, a cardiac cause could be excluded. During long-term follow-up, no coronary heart diseases were diagnosed.
These reports indicate that chest pain seems to be associated with the use of bupropion, but its origin remains unclear.
调查使用安非他酮辅助戒烟时胸痛的原因。
荷兰药物警戒中心收到22例与使用安非他酮辅助戒烟相关的胸痛报告。收集了关于长期随访的更多信息，以分析这些主诉是否预示着明显的心脏病。
除1例患者外，所有患者在停用安非他酮后均康复。另外对7例患者进行了调查，其中6例可排除心脏病因。在长期随访中，未诊断出冠心病。
这些报告表明胸痛似乎与使用安非他酮有关，但其原因尚不清楚。
