Macoris Maria de Lourdes G, Andrighetti Maria Teresa M, Takaku Luiz, Glasser Carmen M, Garbeloto Vanessa C, Bracco José Eduardo
Núcleo de Pesquisa, Serviço Regional, Sucen, Marília, SP, Brasil.
Mem Inst Oswaldo Cruz. 2003 Jul;98(5):703-8. doi: 10.1590/s0074-02762003000500020. Epub 2003 Sep 8.
Since the reintroduction of Aedes aegypti in the state of S o Paulo, in the middle of the 1980-decade, organophosphate insecticides are being used to control the dengue vector. In 1996, an annual program for monitoring the susceptibility of Ae. aegypti to the insecticides was implemented. Some of the results of this monitoring program are presented. Ae. aegypti populations from ten localities have been submitted to bioassays with the diagnostic dose of temephos and fenitrothion. Only two (Mar lia and Presidente Prudente) remain susceptible to both insecticides and one (Santos) exhibits true resistance. Ae. aegypti from the remaining localities showed an incipient altered susceptibility. Resistance ratios varied from 1.2 to 2.9 for temephos and from 1.5 to 3.2 to fenitrothion, indicating moderate levels of resistance. Biochemical assays did not detect alterations in the enzyme acetilcholinesterase, but indicated that resistance is associated with esterases.
自20世纪80年代中期埃及伊蚊重新引入圣保罗州以来，有机磷杀虫剂一直被用于控制登革热媒介。1996年，实施了一项监测埃及伊蚊对杀虫剂敏感性的年度计划。本文介绍了该监测计划的一些结果。来自十个地区的埃及伊蚊种群已接受了对硫磷和杀螟硫磷诊断剂量的生物测定。只有两个地区（玛丽亚镇和普鲁登特总统镇）对这两种杀虫剂仍敏感，一个地区（桑托斯）表现出真正的抗性。其余地区的埃及伊蚊显示出初期的易感性改变。对硫磷的抗性比率从1.2到2.9不等，杀螟硫磷的抗性比率从1.5到3.2不等，表明抗性处于中等水平。生化分析未检测到乙酰胆碱酯酶的变化，但表明抗性与酯酶有关。
