Morgan-Hughes G J, Owens P E, Roobottom C A, Marshall A J
Plymouth NHS Trust, Plymouth, UK.
Heart. 2003 Oct;89(10):1191-4. doi: 10.1136/heart.89.10.1191.
To assess a new multislice computed tomography (CT) technique for three dimensional quantification of aortic valve calcification volume (3D AVCV) and to study the relation between stenosis and calcification of the aortic valve.
50 patients with echocardiographic calcification of the aortic valve underwent two separate ECG triggered multislice CT for quantification of 3D AVCV. The agreement between the two 3D AVCV scores was assessed and 3D AVCV was compared with echocardiographic markers of severity of aortic stenosis.
Overall the level of agreement between the two 3D AVCV scores was excellent (median interscan variability 7.9% (interquartile range 10.1); correlation coefficient, r = 0.99; repeatability coefficient 237.8 mm3 (limits of agreement -393 to 559 mm3)). However, the magnitude of the 3D AVCV did influence the interscan variability. The 3D AVCV correlated closely with the maximal predicted transvalvar gradient (r2 = 0.77) and aortic valve area (r2 = 0.73).
Multislice CT provides a technique for quantifying 3D AVCV that has good reproducibility. There is a close non-linear relation between echocardiographic parameters of severity of valve stenosis and 3D AVCV scores.
评估一种用于三维定量主动脉瓣钙化体积（3D AVCV）的新型多层计算机断层扫描（CT）技术，并研究主动脉瓣狭窄与钙化之间的关系。
50例经超声心动图检查发现主动脉瓣钙化的患者接受了两次独立的心电图触发多层CT检查，以定量3D AVCV。评估了两次3D AVCV评分之间的一致性，并将3D AVCV与主动脉狭窄严重程度的超声心动图指标进行了比较。
总体而言，两次3D AVCV评分之间的一致性水平极佳（扫描间中位数变异性为7.9%（四分位间距为10.1）；相关系数r = 0.99；重复性系数为237.8 mm3（一致性界限为-393至559 mm3））。然而，3D AVCV的大小确实影响了扫描间变异性。3D AVCV与最大预测跨瓣压差（r2 = 0.77）和主动脉瓣面积（r2 = 0.73）密切相关。
多层CT提供了一种定量3D AVCV的技术，具有良好的可重复性。瓣膜狭窄严重程度的超声心动图参数与3D AVCV评分之间存在密切的非线性关系。
