Chandran Krishnan B
Department of Biomedical Engineering, 1402 SC, College of Engineering, University of Iowa, Iowa City, IA 52242, USA.
Cardiovasc Eng Technol. 2010 Mar;1(1):18-38. doi: 10.1007/s13239-010-0002-x.
Computational simulations are playing an increasingly important role in enhancing our understanding of the normal human physiological function, etiology of diseased states, surgical and interventional planning, and in the design and evaluation of artificial implants. Researchers are taking advantage of computational simulations to speed up the initial design of implantable devices before a prototype is developed and hence able to reduce animal experimentation for the functional evaluation of the devices under development. A review of the reported studies to date relevant to the simulation of the native and prosthetic heart valve dynamics is the subject of the present paper. Potential future directions toward multi-scale simulation studies for our further understanding of the physiology and pathophysiology of heart valve dynamics and valvular implants are also discussed.
计算机模拟在增进我们对正常人体生理功能、疾病状态的病因、手术和介入规划以及人工植入物的设计与评估等方面发挥着越来越重要的作用。研究人员利用计算机模拟在可植入设备原型开发之前加速其初始设计，从而能够减少对正在开发的设备进行功能评估的动物实验。本文综述了迄今为止与天然和人工心脏瓣膜动力学模拟相关的已报道研究。还讨论了未来多尺度模拟研究的潜在方向，以进一步了解心脏瓣膜动力学和瓣膜植入物的生理学及病理生理学。
