Hamamori Yasuo, Schneider Michael D
Center for Cardiovascular Development, Baylor College of Medicine, One Baylor Plaza, Room 506D, Houston, Texas 77030, USA.
J Clin Invest. 2003 Sep;112(6):824-6. doi: 10.1172/JCI19834.
Histone acetylation, regulated by two antagonistic enzymes - histone acetyltransferases (HATs) and histone deacetylases (HDACs) - results in transcriptional changes and also plays a critical role in cardiac development and disease. A new study shows that overexpression of the atypical transcriptional corepressor homeodomain-only protein (Hop) causes cardiac hypertrophy via recruitment of a class I HDAC. In contrast to the body of work on transcriptional mechanisms that drive cardiac hypertrophy, including class II HDACs, this report elucidates a novel growth-suppressing transcriptional pathway in cardiac muscle that opposes hypertrophic growth.
组蛋白乙酰化受两种拮抗酶——组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）调控，可导致转录变化，并且在心脏发育和疾病中也起着关键作用。一项新研究表明，非典型转录共抑制因子仅含同源结构域蛋白（Hop）的过表达通过募集I类HDAC导致心脏肥大。与关于驱动心脏肥大的转录机制（包括II类HDACs）的大量研究工作不同，本报告阐明了心肌中一条与肥大生长相反的新型生长抑制转录途径。
