Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.
Diabetologia. 2014 Apr;57(4):660-71. doi: 10.1007/s00125-014-3171-6. Epub 2014 Jan 30.
In recent years, diabetes mellitus has become an epidemic and now represents one of the most prevalent disorders. Cardiovascular complications are the major cause of mortality and morbidity in diabetic patients. While ischaemic events dominate the cardiac complications of diabetes, it is widely recognised that the risk for developing heart failure is also increased in the absence of overt myocardial ischaemia and hypertension or is accelerated in the presence of these comorbidities. These diabetes-associated changes in myocardial structure and function have been called diabetic cardiomyopathy. Numerous molecular mechanisms have been proposed to contribute to the development of diabetic cardiomyopathy following analysis of various animal models of type 1 or type 2 diabetes and in genetically modified mouse models. The steady increase in reports presenting novel mechanistic data on this subject expands the list of potential underlying mechanisms. The current review provides an update on molecular alterations that may contribute to the structural and functional alterations in the diabetic heart.
近年来，糖尿病已成为一种流行病，现在是最常见的疾病之一。心血管并发症是糖尿病患者死亡和发病的主要原因。虽然缺血事件是糖尿病心脏并发症的主要原因，但人们普遍认识到，即使没有明显的心肌缺血、高血压或这些合并症存在，发生心力衰竭的风险也会增加。这些与糖尿病相关的心肌结构和功能变化被称为糖尿病心肌病。通过对 1 型和 2 型糖尿病的各种动物模型以及基因修饰的小鼠模型进行分析，提出了许多分子机制来解释糖尿病心肌病的发生。关于这个主题的新的机制数据的不断增加，扩展了潜在机制的清单。本综述提供了关于可能导致糖尿病心脏结构和功能改变的分子改变的最新信息。
