Fonseca E, Alvarez R, González M R, Pascual D
Department of Dermatology, Hospital La Paz, Madrid, Spain.
Lupus. 1992 Aug;1(4):265-8. doi: 10.1177/096120339200100411.
We examined the prevalence of the antibodies to cardiolipin measured by solid-phase enzyme immunoassay during a prospective study of patients with subacute cutaneous lupus erythematosus (SCLE). Seven of 44 (16%) consecutive patients with SCLE had positive anticardiolipin antibodies; of these only three satisfied the American Rheumatism Association's revised criteria for the classification of systemic lupus erythematosus. Clinical findings probably associated with the positive anticardiolipin antibodies were found in four cases, including clotting abnormalities, thrombocytopenia, hemolytic anemia, livedo reticularis, chilblain lupus erythematosus lesions, migraine, leg venous thrombosis and pulmonary embolism after surgery, and spontaneous abortion. Our data suggest that it is reasonable to screen SCLE patients for these antibodies to confirm the presence of the antiphospholipid syndrome.
在一项对亚急性皮肤型红斑狼疮（SCLE）患者的前瞻性研究中，我们通过固相酶免疫测定法检测了抗心磷脂抗体的流行情况。44例连续的SCLE患者中有7例（16%）抗心磷脂抗体呈阳性；其中只有3例符合美国风湿病协会修订的系统性红斑狼疮分类标准。在4例患者中发现了可能与抗心磷脂抗体阳性相关的临床症状，包括凝血异常、血小板减少、溶血性贫血、网状青斑、冻疮样红斑狼疮皮损、偏头痛、腿部静脉血栓形成和术后肺栓塞，以及自然流产。我们的数据表明，对SCLE患者进行这些抗体筛查以确诊抗磷脂综合征是合理的。
