China Institute of Sport Science, 11 Tiyuguan Road, Dongcheng District, Beijing 100061, China.
Sensors (Basel). 2012;12(5):5586-95. doi: 10.3390/s120505586. Epub 2012 May 2.
It has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pre- and post-exercise human serum on concanavalin A stimulated lymphocyte proliferation of mice. In the present study, blood samples in eight male undergraduates (age 21 ± 0.7 years) were taken before and immediately after ten sets of exercise consisting of 15 free and 30 10-kg loaded squat jumps in each set. The suppression of lymphocyte proliferation was analysed with high pressure liquid chromatography. It was noted from the result of gel chromatography columns that the post-exercise values of the suppression of lymphocyte proliferation, in comparison to corresponding pre-exercise values, were generally greater with significant differences observed in 7.5th-9th min post-exercise eluates (P < 0.05). Such findings suggest that intense eccentric type exercise may lead to generation of immunosuppressive factor(s) in young males.
已经证明，在特定的压力下，动物和人类会产生一种作为免疫抑制剂的抑制蛋白。然而，与急性运动引起的应激相关的免疫抑制因子的研究还很有限。本研究比较了运动前和运动后人体血清对刀豆蛋白 A 刺激的小鼠淋巴细胞增殖的影响。在本研究中，对 8 名男性大学生（年龄 21±0.7 岁）进行了 10 组运动的血液样本采集，每组运动包括 15 次自由深蹲跳和 30 次 10 公斤负重深蹲跳。淋巴细胞增殖的抑制作用采用高压液相色谱法进行分析。从凝胶色谱柱的结果可以看出，与相应的运动前值相比，运动后淋巴细胞增殖抑制率的值通常更高，在运动后第 7.5-9 分钟洗脱液中观察到显著差异（P<0.05）。这些发现表明，剧烈的离心型运动可能导致年轻男性产生免疫抑制因子。
