肺炎球菌粘肽和荚膜多糖对吞噬作用的影响。
Effects of pneumococcal mucopeptide and capsular polysaccharide on phagocytosis.
作者信息
Dhingra R K, Williams R C, Reed W P
出版信息
Infect Immun. 1977 Jan;15(1):169-74. doi: 10.1128/iai.15.1.169-174.1977.
Abstract
Pneumoccal cell wall and capsular products from eight serotypes were tested for their ability to inhibit polymorphonuclear neutrophil killing of the same eight pneumococcal strains. Crude pneumococcal cell wall preparations from all serotypes inhibited phagocytic killing of several pneumococcal serotypes, and were just as effective with heterologous as with homologous strains. Phagocytosis dependent on heat-labile serum factors was inhibited, whereas phagocytosis not dependent on heat-labile factors was not significantly affected. These findings were compatible with inhibition of complement consumption. The inhibitory activity was found in a purified cell wall mucopeptide, whereas purified capsular polysaccharides failed to inhibit phagocytosis.
摘要
对来自八种血清型的肺炎球菌细胞壁和荚膜产物进行了测试，以检验它们抑制多形核中性粒细胞对相同八种肺炎球菌菌株杀伤作用的能力。所有血清型的粗制肺炎球菌细胞壁制剂均能抑制几种肺炎球菌血清型的吞噬杀伤作用，对异源菌株和同源菌株的效果相同。依赖于热不稳定血清因子的吞噬作用受到抑制，而不依赖热不稳定因子的吞噬作用则未受到显著影响。这些发现与补体消耗的抑制作用相符。在纯化的细胞壁粘肽中发现了抑制活性，而纯化的荚膜多糖未能抑制吞噬作用。
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