链球菌细胞壁片段对吞噬作用和组织培养细胞的影响。
Effects of streptococcal cell wall fragments on phagocytosis and tissue culture cells.
机构信息
Department of Bacteriology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514.
出版信息
Infect Immun. 1970 Mar;1(3):232-42. doi: 10.1128/iai.1.3.232-242.1970.
Abstract
Group A streptococcal cell wall fragments inhibited phagocytosis of unrelated particles by rabbit polymorphonuclear leukocytes and inhibited the growth of rabbit kidney cells in vitro. Activity was associated with the mucopeptide moiety. Whole streptococci or the cytoplasmic fraction were less effective than cell wall fragments. The cell wall fragments of group D streptococci, Bacillus megaterium, and Escherichia coli were inactive. The inhibition of phagocytosis illustrates one way in which microbial components may influence the immune response. The toxicity for tissue cultures of rabbit kidney cell monolayers was greatest during the phase of active cell division. This appears to be a direct toxic effect of cell wall fragments on mammalian cells and may be related to the in vivo injury previously reported for streptococcal cell walls.
摘要
A 组链球菌细胞壁片段可抑制兔多形核白细胞吞噬无关颗粒，并抑制兔肾细胞在体外生长。活性与粘肽部分有关。全链球菌或细胞质部分的效果不如细胞壁片段。D 组链球菌、巨大芽孢杆菌和大肠杆菌的细胞壁片段没有活性。吞噬作用的抑制说明了微生物成分影响免疫反应的一种方式。在兔肾细胞单层的活跃细胞分裂阶段，对组织培养物的毒性最大。这似乎是细胞壁片段对哺乳动物细胞的直接毒性作用，可能与先前报道的链球菌细胞壁的体内损伤有关。
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