Claeys F, Ducoffre G, Sartor F, Roels H
Institute of Hygiene and Epidemiology, Epidemiology Unit, Brussels, Belgium.
IARC Sci Publ. 1992(118):83-92.
Quality-control programmes are very important in assessing the reliability of biological analyses. Such programmes are essential if misleading results in epidemiological studies dealing with low levels of exposure to heavy metals present in the general environment (e.g., cadmium, lead) are to be avoided. Internal and external quality-control programmes for the measurement of cadmium and lead in blood and of cadmium in urine were implemented from 1985 to 1989 in support of a national epidemiological study, Cadmibel (2327 participants), conducted in Belgium to assess the effects of environmental exposure to cadmium and lead on the general population. Apart from these programmes, inter-comparisons between the two participating laboratories were carried out on 10% of the samples. The results of these quality-control programmes met external acceptability criteria, emphasizing the analytical proficiency of these measurements at the relatively low concentrations in the Cadmibel study.
质量控制程序对于评估生物学分析的可靠性非常重要。如果要避免在涉及一般环境中低水平重金属暴露（如镉、铅）的流行病学研究中得出误导性结果，此类程序必不可少。1985年至1989年期间实施了血液中镉和铅以及尿液中镉测量的内部和外部质量控制程序，以支持在比利时进行的一项全国性流行病学研究——Cadmibel（2327名参与者），该研究旨在评估环境中镉和铅暴露对普通人群的影响。除了这些程序外，还对10%的样本在两个参与实验室之间进行了比对。这些质量控制程序的结果符合外部可接受标准，强调了在Cadmibel研究中相对低浓度下这些测量的分析熟练度。
