Salvato A R, Clark G E, Gingold J, Curro F A
Block Drug Company, Jersey City, NJ 07302-9988.
Am J Dent. 1992 Dec;5(6):303-6.
Sensodyne F, a dentifrice currently marketed in the United Kingdom, containing potassium chloride (KCl) and sodium monofluorophosphate (MFP) was compared to a placebo dentifrice for effectiveness in alleviating dentinal hypersensitivity. This randomized, double-blind, parallel clinical study covered 12 weeks of product use by 41 subjects. Hypersensitivity levels of the affected teeth were assessed by tactile stimulation, cold air stimulation and overall subjective patient response. The results from these three methods of assessment demonstrated that the KCl/MFP dentifrice was significantly more effective than the placebo dentifrice in reducing dentinal hypersensitivity. The therapeutic response to the KCl/MFP dentifrice as measured by air sensitivity and overall subjective evaluation was statistically significant when compared to the placebo dentifrice within 4 weeks of use. Significant improvement was observed for all parameters at the conclusion of the 12-week clinical study period. Plaque reduction was significantly reduced at week 8 and continued to improve by week 12. The results indicate that KCl with sodium MFP significantly reduced dentinal hypersensitivity and improved overall patient comfort.
舒适达F牙膏目前在英国销售，含有氯化钾（KCl）和单氟磷酸钠（MFP），将其与一款安慰剂牙膏进行比较，以评估其缓解牙本质过敏的效果。这项随机、双盲、平行的临床研究涵盖了41名受试者使用产品的12周时间。通过触觉刺激、冷空气刺激以及患者的总体主观反应来评估患牙的过敏水平。这三种评估方法的结果表明，含KCl/MFP的牙膏在降低牙本质过敏方面比安慰剂牙膏显著更有效。与安慰剂牙膏相比，在使用KCl/MFP牙膏4周内，通过空气敏感性和总体主观评价测得的治疗反应具有统计学意义。在为期12周的临床研究期结束时，所有参数均有显著改善。在第8周时牙菌斑减少显著，并持续改善至第12周。结果表明，KCl与单氟磷酸钠能显著降低牙本质过敏并提高患者的总体舒适度。
