Silverman G, Gingold J, Curro F A
Am J Dent. 1994 Feb;7(1):9-12.
Sensodyne F is a potassium chloride (KCl) and sodium monofluorphosphate (MFP) containing dentifrice currently marketed in the United Kingdom and Germany was compared to a KCl only dentifrice and to a placebo dentifrice for effectiveness in alleviating dentin hypersensitivity. This 3-cell, randomized, double-blind, parallel clinical study utilized 62 subjects for an 8-week duration of product use. The degree of hypersensitivity of the affected teeth was assessed by tactile stimulation, cold air stimulation and overall subjective patient response. The results from these three methods of assessment indicated that a KCl containing dentifrice either alone or in combination with sodium MFP were significantly more effective than the placebo dentifrice in reducing dentin hypersensitivity. The therapeutic response to the KCl dentifrices as measured by air sensitivity and tactile sensitivity was statistically significant when compared to the placebo dentifrice within 4 weeks of use. Significant improvement was seen for all parameters at the conclusion of the 8-week clinical study period. Plaque reduction was significantly reduced at 8 weeks. The results indicate that KCl is an efficacious molecule in reducing dentin hypersensitivity when used either alone or in combination with sodium MFP as measured by improved overall patient comfort.
舒适达F是一种含氯化钾（KCl）和单氟磷酸钠（MFP）的牙膏，目前在英国和德国销售。将其与仅含KCl的牙膏和安慰剂牙膏进行比较，以评估其缓解牙本质过敏的效果。这项三单元、随机、双盲、平行的临床研究共纳入62名受试者，使用产品为期8周。通过触觉刺激、冷空气刺激以及患者的总体主观反应来评估患牙的过敏程度。这三种评估方法的结果表明，含KCl的牙膏，无论是单独使用还是与MFP联合使用，在降低牙本质过敏方面都比安慰剂牙膏显著更有效。在使用4周内，与安慰剂牙膏相比，KCl牙膏在空气敏感性和触觉敏感性方面的治疗反应具有统计学意义。在8周临床研究期结束时，所有参数均有显著改善。8周时牙菌斑减少显著。结果表明，以患者总体舒适度提高来衡量，KCl单独使用或与MFP联合使用时，都是减轻牙本质过敏的有效成分。
