Yang W X
Henan Cancer Institute, Zhengzhou.
Zhonghua Zhong Liu Za Zhi. 1992 Nov;14(6):407-10.
A total of 391 gastric juice samples was collected from Ji Yuan and An Shi counties, high and medium risk areas of esophageal carcinoma in Henan province. NDMA, NDEA, NMBzA, NPip and unknown compounds were assayed in the fasting gastric juice. Among these nitrosamines, NMBzA, NPyr and NPip were specific in inducing esophageal cancer in animals. The amount of nitrosamines in the gastric juice collected from Ji Yuan county was higher than that from An Shi county. The exposure level of nitrosamines of subjects from these two localities were significantly different (P < 0.001). There was a positive relationship between the nitrosamines exposure level and esophageal cancer mortality rate. The amount of gastric N-nitrosamines from An Shi subjects as treated with vitamin C was reduced. It is evident that vitamin C can inhibit N-nitrosamine formation in the stomach, thereby, reducing the N-nitrosamines exposure level.
共采集了河南省食管癌高、中风险地区济源市和安阳市的391份胃液样本。对空腹胃液中的N-亚硝基二甲胺（NDMA）、N-亚硝基二乙胺（NDEA）、N-亚硝基甲基苄胺（NMBzA）、N-亚硝基哌啶（NPip）及未知化合物进行了检测。在这些亚硝胺中，NMBzA、N-亚硝基吡咯（NPyr）和NPip在动物体内具有诱导食管癌的特异性。济源市采集的胃液中亚硝胺含量高于安阳市。这两个地区受试者的亚硝胺暴露水平存在显著差异（P<0.001）。亚硝胺暴露水平与食管癌死亡率呈正相关。安阳市受试者经维生素C处理后，胃内N-亚硝胺含量降低。显然，维生素C可抑制胃内亚硝胺的形成，从而降低N-亚硝胺的暴露水平。
