Contreras M, Ala F A, Greaves M, Jones J, Levin M, Machin S J, Morgan C, Murphy W, Napier J A, Thomson A R
British Society for Haematology, London, U.K.
Transfus Med. 1992 Mar;2(1):57-63. doi: 10.1111/j.1365-3148.1992.tb00135.x.
Fresh frozen plasma should only be used to treat bleeding episodes or prepare patients for surgery in certain defined situations. Definite indications for the use of FFP: 1. Replacement of single coagulation factor deficiencies, where a specific or combined factor concentrate is unavailable. 2. Immediate reversal or warfarin effect. 3. Acute disseminated intravascular coagulation (DIC). 4. Thrombotic thrombocytopenic purpura (TTP). Conditional uses: FFP only indicated in the presence of bleeding and disturbed coagulation: 1. Massive transfusion. 2. Liver disease. 3. cardiopulmonary bypass surgery. 4. Special paediatric indications. No justification for the use of FFP: 1. Hypovolaemia. 2. Plasma exchange procedures. 3. 'Formula' replacement. 4. Nutritional support. 5. Treatment of immunodeficiency states.
新鲜冰冻血浆仅应用于治疗出血发作或在某些特定情况下为患者手术做准备。使用新鲜冰冻血浆的明确指征：1. 单一凝血因子缺乏的替代治疗，此时缺乏特定的或联合的因子浓缩物。2. 华法林效应的立即逆转。3. 急性弥散性血管内凝血（DIC）。4. 血栓性血小板减少性紫癜（TTP）。有条件的用途：新鲜冰冻血浆仅在存在出血和凝血紊乱时使用：1. 大量输血。2. 肝脏疾病。3. 体外循环手术。4. 特殊儿科指征。使用新鲜冰冻血浆无正当理由的情况：1. 血容量不足。2. 血浆置换程序。3. “配方”替代。4. 营养支持。5. 免疫缺陷状态的治疗。
