Ziboh V A, Fletcher M P
Department of Dermatology, University of California, Davis 95616.
Am J Clin Nutr. 1992 Jan;55(1):39-45. doi: 10.1093/ajcn/55.1.39.
The dose-dependent effect of dietary supplemented gamma-linolenic acid (GLA, 18:3n-6)-enriched borage oil (Bor) and black-currant oil on the ability of calcium ionophore-activated human polymorphonuclear neutrophils (PMN) to generate leukotriene B4 (LTB4) was investigated in adult healthy human volunteers. Significant (P less than 0.05) elevation of dihomo-gamma-linolenic acid (DGLA, 20:3n-6), an elongation product of GLA, was revealed in PMN phospholipids after ingestion of either 0.48 or 1.5 g GLA-enriched oil/d. This elevation of DGLA in the PMN phospholipids paralleled the decreased capacity of calcium ionophore-activated PMN to generate LTB4. Although the inhibition of LTB4 was greater with the ingestion of 1.5 g GLA-enriched BOR/d, it was not significantly different from the ingestion of 0.48 g/d. Taken together, dietary ingestion of GLA-fortified oils does modulate PMN generation of proinflammatory LTB4.
在成年健康人类志愿者中，研究了膳食补充富含γ-亚麻酸（GLA，18:3n-6）的琉璃苣油（Bor）和黑加仑油对钙离子载体激活的人多形核中性粒细胞（PMN）生成白三烯B4（LTB4）能力的剂量依赖性影响。摄入0.48或1.5克富含GLA的油/天后，PMN磷脂中GLA的延长产物二高-γ-亚麻酸（DGLA，20:3n-6）显著（P<0.05）升高。PMN磷脂中DGLA的这种升高与钙离子载体激活的PMN生成LTB4的能力下降平行。虽然每天摄入1.5克富含GLA的BOR时对LTB4的抑制作用更大，但与每天摄入0.48克并无显著差异。综上所述，膳食摄入富含GLA的油确实会调节PMN促炎性LTB4的生成。
