Wong K F, Chan J K, Ng C S, Chu Y C, Lam P W, Yuen H L
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Am J Hematol. 1991 Jun;37(2):112-9. doi: 10.1002/ajh.2830370209.
This report describes the bone marrow findings in four patients whose marrow was involved by anaplastic large-cell Ki-1 lymphoma, an uncommon event in this type of lymphoma. In the marrow aspirate smears, the involvement was subtle, and was in the form of isolated large cells with irregular nuclear configuration, coarse chromatin, prominent nucleoli, and basophilic cytoplasm which might be vacuolated. One case showed paradoxically massive involvement in the trephine biopsy taken from the same site as the marrow aspirate. Reactive histiocytic proliferation with hemophagocytosis was also present. Since marrow aspirate or biopsy may be the first pathologic specimen examined in patients having anaplastic large-cell Ki-1 lymphoma, it is important to be able to recognize the small population of neoplastic cells, which should lead to prompt treatment or further investigations as deemed necessary.
本报告描述了4例骨髓被间变性大细胞Ki-1淋巴瘤累及患者的骨髓检查结果，这种情况在该类型淋巴瘤中并不常见。在骨髓穿刺涂片上，累及情况不明显，表现为单个大细胞，核形态不规则，染色质粗糙，核仁突出，胞质嗜碱性，可能有空泡。1例患者在与骨髓穿刺同一部位所取的环钻活检中显示出异常广泛的累及。还存在伴有噬血细胞现象的反应性组织细胞增生。由于骨髓穿刺或活检可能是间变性大细胞Ki-1淋巴瘤患者首先接受检查的病理标本，因此能够识别少量肿瘤细胞很重要，这应能促使及时治疗或根据需要进行进一步检查。
