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脑膜血管外皮细胞瘤的形态学及临床意义(作者译)

[Morphology and clinical significance of the meningeal hemangiopericytoma (author's transl)].

作者信息

Kastendieck H, Klöppel G, Altenähr E

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Mar 19;85(3):287-97. doi: 10.1007/BF00284087.

Abstract

Hemangiopericytomas of the meninges are rare tumors. Three tumors of this type with a course over more than 10 years each are reported. All three tumors were primary diagnosed as meningiomas (one: vascular, two angioblastic). The diagnosis was changed to hemangiopericytoma only then when recurrences and extracranial metastases had occurred. Morphologically, "angioblastic meningioma" and "hemangiopericytoma of the meninges" show striking common features. The principal pattern bases on the blastomatous increase of capillary blood vessels lined by a normal endothelium, extracapillary proliferation of pericyte-like mesenchymal cells and an intercellular network of reticulin fibres. Light- and electron microsopic findings do not demonstrate the characteristics of a meningioma. Furthermore, clinical data and growth pattern of "angioblastic meningioma" and "hemangiopericytoma of the meninges" are well comparable. Therefore, it seems to be justified to interpret these tumors as a tumor entity with identical histogenesis. It is well known that hemangiopericytomas frequently recur and metastasise. On the other hand, meningiomas are usually benign. For those reasons we suggest that these tumors should be uniformly classified as "hemangiopericytoma of the meninges" in order to stress the significance of these particular tumors of the meninges regarding their treatment and behaviour.

摘要

脑膜血管外皮细胞瘤是罕见肿瘤。本文报告了3例病程均超过10年的该类肿瘤。所有3例肿瘤最初均被诊断为脑膜瘤(1例:血管性,2例血管母细胞性)。仅在出现复发和颅外转移时,诊断才改为血管外皮细胞瘤。形态学上,“血管母细胞性脑膜瘤”和“脑膜血管外皮细胞瘤”表现出显著的共同特征。主要模式基于由正常内皮细胞衬里的毛细血管的母细胞瘤样增生、周细胞样间充质细胞的毛细血管外增生以及网状纤维的细胞间网络。光镜和电镜检查结果未显示脑膜瘤的特征。此外,“血管母细胞性脑膜瘤”和“脑膜血管外皮细胞瘤”的临床资料和生长模式具有很好的可比性。因此,将这些肿瘤解释为具有相同组织发生的肿瘤实体似乎是合理的。众所周知,血管外皮细胞瘤经常复发和转移。另一方面,脑膜瘤通常是良性的。基于这些原因,我们建议将这些肿瘤统一归类为“脑膜血管外皮细胞瘤”,以强调这些特殊的脑膜肿瘤在治疗和行为方面的重要性。

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