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Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole.

作者信息

Simeon A, van der Klei I J, Veenhuis M, Wolf D H

机构信息

Institut für Biochemie, Universität Stuttgart, Germany.

出版信息

FEBS Lett. 1992 Apr 20;301(2):231-5. doi: 10.1016/0014-5793(92)81254-j.

DOI:10.1016/0014-5793(92)81254-j
PMID:1314742
Abstract

Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

摘要

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Microbiol Mol Biol Rev. 1998 Mar;62(1):230-47. doi: 10.1128/MMBR.62.1.230-247.1998.
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