Cox M F, Eveson J, Porter S R, Maitland N, Scully C
Centre for the Study of Oral Disease, Bristol, England.
Oral Surg Oral Med Oral Pathol. 1992 Apr;73(4):476-8. doi: 10.1016/0030-4220(92)90329-o.
White sponge nevus (WSN) is a benign hereditary lesion of the mucous membranes. DNA extracted from a biopsy specimen of oral WSN was assayed for the presence of DNA sequences homologous to human papillomavirus (HPV) types 1, 2, 4, 6, 11, 13, 16, and 18 by Southern blot hybridization. Only HPV-16 homologous DNA sequences were detected at a copy number of approximately 200 to 250 genome copies per diploid cell. The viral DNA sequences did not appear to be integrated into the host cell chromosome. The finding of HPV-16 in an inherited lesion such as WSN indicates that caution must be exercised in ascribing a causal association in relation to the demonstration of HPV in other mucosal disorders.
白色海绵状痣（WSN）是一种良性的黏膜遗传性病变。通过Southern印迹杂交法，对从口腔白色海绵状痣活检标本中提取的DNA进行检测，以确定是否存在与人乳头瘤病毒（HPV）1、2、4、6、11、13、16和18型同源的DNA序列。仅检测到HPV - 16同源DNA序列，每个二倍体细胞的拷贝数约为200至250个基因组拷贝。病毒DNA序列似乎未整合到宿主细胞染色体中。在诸如白色海绵状痣这样的遗传性病变中发现HPV - 16表明，在将HPV的存在与其他黏膜疾病的因果关系联系起来时必须谨慎。
