氯乙烯病发病机制中的免疫机制。
Immunological mechanisms in the pathogenesis of vinyl chloride disease.
作者信息
Ward A M, Udnoon S, Watkins J, Walker A E, Darke C S
出版信息
Br Med J. 1976 Apr 17;1(6015):936-8. doi: 10.1136/bmj.1.6015.936.
Abstract
Vinyl chloride (VC) disease is a multisystem disorder incorporating Raynaud's phenomenon, acro-osteolysis, thrombocytopenia, portal fibrosis, and hepatic and pulmonary dysfunction. Immunological and immunochemical investigations showed the presence of circulating immune complexes in 19 out of 28 patients with the disease and in a further two out of 30 workers exposed to VC. The immunological data were reviewed in relation to the clinical picture of the disease and to the available evidence on the metabolism of VC. The results suggest that VC disease is an immune complex disorder and that the immune response is initiated by the adsorption of VC or a metabolite on to tissue or plasma protein.
摘要
氯乙烯（VC）病是一种多系统疾病，包括雷诺现象、肢端骨质溶解、血小板减少、门静脉纤维化以及肝和肺功能障碍。免疫和免疫化学研究表明，28例该病患者中有19例以及另外30名接触VC的工人中有2例存在循环免疫复合物。结合该病的临床症状以及关于VC代谢的现有证据对免疫数据进行了综述。结果表明，VC病是一种免疫复合物疾病，免疫反应是由VC或其代谢产物吸附到组织或血浆蛋白上引发的。
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