Brillanti S, Masci C, Ricci P, Miglioli M, Barbara L
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy.
Hepatology. 1992 Jun;15(6):998-1001. doi: 10.1002/hep.1840150604.
We assessed the correlation between the positivity for serum IgM antibody to hepatitis C virus and the activity of liver disease in patients with chronic hepatitis C virus infection. Serum samples were taken from 10 antibody to hepatitis C virus-positive asymptomatic patients with normal serum ALT levels, from 14 untreated patients with clinically and histologically proven chronic hepatitis C and from 26 patients with clinically and histologically proven chronic hepatitis C assigned to receive recombinant interferon alpha-2a (6 million IU three times a week for 6 mo). Each serum specimen was tested for IgM antibody to hepatitis C virus-associated C100-3 antigen by enzyme-linked immunosorbent assay. Patients were observed for at least 12 mo. All 10 patients with normal ALT values tested negative for IgM antibody to hepatitis C virus. In contrast, 33 of 40 (82%) patients with chronic hepatitis C had IgM antibody to hepatitis C virus, and a positive correlation was seen between the ALT level and the level of IgM antibody to hepatitis C virus (r = 0.803, p less than 0.001). During interferon treatment, ALT levels declined into the normal range in 18 of 26 treated patients (69%) and remained normal after stopping treatment in 8 patients (31%). In untreated patients, in treated patients who did not respond to interferon treatment and in responder patients who relapsed, no significant changes in IgM antibody to hepatitis C virus levels were seen during the study period. In contrast, IgM antibody to hepatitis C virus became undetectable by the end of interferon treatment in seven of eight patients with a sustained response.(ABSTRACT TRUNCATED AT 250 WORDS)
我们评估了慢性丙型肝炎病毒感染患者血清抗丙型肝炎病毒IgM抗体阳性与肝脏疾病活动度之间的相关性。血清样本取自10例抗丙型肝炎病毒阳性、血清ALT水平正常的无症状患者，14例经临床和组织学证实为慢性丙型肝炎的未治疗患者，以及26例经临床和组织学证实为慢性丙型肝炎且被分配接受重组干扰素α-2a治疗的患者（600万国际单位，每周3次，共6个月）。通过酶联免疫吸附试验检测每份血清标本中抗丙型肝炎病毒相关C100-3抗原的IgM抗体。对患者进行了至少12个月的观察。所有10例ALT值正常的患者抗丙型肝炎病毒IgM抗体检测均为阴性。相比之下，40例慢性丙型肝炎患者中有33例（82%）抗丙型肝炎病毒IgM抗体阳性，且ALT水平与抗丙型肝炎病毒IgM抗体水平之间呈正相关（r = 0.803，p<0.001）。在干扰素治疗期间，26例接受治疗的患者中有18例（69%）ALT水平降至正常范围，8例患者（31%）在停止治疗后仍保持正常。在未治疗的患者、对干扰素治疗无反应的治疗患者以及复发的有反应患者中，在研究期间抗丙型肝炎病毒IgM抗体水平无显著变化。相比之下，8例持续应答的患者中有7例在干扰素治疗结束时抗丙型肝炎病毒IgM抗体检测不到。（摘要截取自250字）
