L'Abbate A, Cutrupi S, Rognetta M, Fabiano C, Craxi A
Centre of Clinical Physiology, C.N.R., Reggio Calabria, Italy.
Clin Exp Immunol. 1993 Nov;94(2):313-6. doi: 10.1111/j.1365-2249.1993.tb03449.x.
To assess the relationship between hepatitis C virus (HCV) infection and essential mixed cryoglobulinaemia (EMC), sera from 23 patients with EMC were tested for IgG and IgM antibodies to HCV antigens and for HCV RNA. Quantitative HCV antibody studies were performed on serum and purified cryoglobulin fractions. HCV antibodies of both IgG and IgM class were found in 22 (96%) patients. Ten of these were also HCV-RNA positives. Higher titres of anti-HCV IgM were present in the 11 patients with evidence of liver damage. Anti-HCV IgG antibodies were shown to be concentrated in the IgG fraction of cryoglobulins in all eight patients studied. These results strongly suggest a role for HCV in the pathogenesis of EMC.
为评估丙型肝炎病毒（HCV）感染与原发性混合性冷球蛋白血症（EMC）之间的关系，对23例EMC患者的血清进行了抗HCV抗原IgG和IgM抗体以及HCV RNA检测。对血清和纯化的冷球蛋白组分进行了HCV抗体定量研究。22例（96%）患者检测到IgG和IgM类HCV抗体。其中10例也是HCV-RNA阳性。11例有肝损伤证据的患者中，抗HCV IgM滴度更高。在所研究的8例患者中，抗HCV IgG抗体均集中在冷球蛋白的IgG组分中。这些结果强烈提示HCV在EMC发病机制中起作用。
