Reddehase M J, Dreher-Stumpp L, Angele P, Balthesen M, Susa M
Department of Virology, Institute for Microbiology, University of Ulm, Federal Republic of Germany.
Ann Hematol. 1992 Jun;64 Suppl:A125-7. doi: 10.1007/BF01715364.
Cytomegalovirus (CMV) recurrence from latency is a major risk factor in bone marrow transplantation (BMT). Owing to the immunodepletive treatment, ablation of the immune control of latent CMV is responsible for recurrence and cytopathogenic spread of the virus in vital tissues. There is increasing evidence for reconstituting bone marrow being itself a target tissue of CMV. By inhibiting post-transplantation hematopoiesis, CMV is causal for maintenance of the immunocompromised state, which leads to a prolonged phase of persistent virus replication. Based on results in a murine model of BMT and concurrent CMV infection, we discuss possible mechanisms of CMV-mediated bone marrow graft failure. It is concluded that an irremediable damage of bone marrow stroma by CMV is responsible for a reduced rate of regeneration of the marrow-repopulating, pluripotent stem cell.
巨细胞病毒（CMV）从潜伏状态复发是骨髓移植（BMT）中的一个主要危险因素。由于免疫清除治疗，潜伏性CMV免疫控制的消除是病毒在重要组织中复发和细胞致病性传播的原因。越来越多的证据表明，重建的骨髓本身就是CMV的靶组织。通过抑制移植后的造血功能，CMV是免疫功能低下状态持续存在的原因，这导致了病毒持续复制的延长阶段。基于BMT和并发CMV感染小鼠模型的结果，我们讨论了CMV介导的骨髓移植失败的可能机制。得出的结论是，CMV对骨髓基质造成的不可修复的损伤是骨髓再填充多能干细胞再生率降低的原因。
