Raveh L, Segall Y, Leader H, Rothschild N, Levanon D, Henis Y, Ashani Y
Israel Institute for Biological Research, Ness-Ziona, Israel.
Biochem Pharmacol. 1992 Jul 22;44(2):397-400. doi: 10.1016/0006-2952(92)90028-h.
We demonstrate here the correlation between protection afforded by pretreatment alone with parathion hydrolase purified from Pseudomonas sp. against tabun toxicity in mice and the kinetic parameters which are assumed to determine the in vivo detoxification of tabun by the same enzyme. Results show that 15 and 22 micrograms of parathion hydrolase per animal conferred a protective ratio of 3.94 and 5.65 respectively, against tabun toxicity, without post-exposure treatment.
我们在此证明，仅用从假单胞菌属纯化的对硫磷水解酶预处理小鼠所提供的对塔崩毒性的保护作用，与假定可决定同一酶在体内对塔崩解毒作用的动力学参数之间的相关性。结果表明，在无暴露后治疗的情况下，每只动物给予15微克和22微克对硫磷水解酶时，对塔崩毒性的保护率分别为3.94和5.65。
